The cytologic diagnosis of follicular variant of papillary thyroid carcinoma (FVPTC) can be difficult owing to the paucity of nuclear changes of papillary carcinoma and overlapping features with other follicular-de rived lesions. Elemental Testing Using Inductively Coupled Plasma Mass Spectrometry in Clinical Laboratories: About American Journal of Clinical Pathology, About the American Society for Clinical Pathology, Receive exclusive offers and updates from Oxford Academic, ThinPrep Versus Conventional Smear Cytologic Preparations in the Analysis of Thyroid Fine-Needle Aspiration Specimens. 1 This paradox is attributed to the fact that we are diagnosing many more nonfatal cases, of which most are minimally invasive and minimally malignant tumors. In this study, we aimed to compare functional status, ultrasonographical features, cytological results, and histopathological characteristics of patients with CPTC and FVPTC. follicular variant of papillary thyroid carcinoma (FVPTC) is the second most common variant; these variants comprise approximately 55%-66% and 11.8%-31.6% of well differentiated thyroid carcinomas, respectively [1-5]. Only 5 cases showed prominent nuclear features of papillary carcinoma. Oxford University Press is a department of the University of Oxford. Histologically the tumors were composed exclusively of follicles (four cases) or an admixture of follicular and trabecular structures (four cases). Mod Pathol. Indiana University School of Medicine . It furthers the University's objective of excellence in research, scholarship, and education by publishing worldwide, This PDF is available to Subscribers Only. Interobserver variation in the We studied cytological specimens of conventional papillary thyroid carcinoma (PTC), follicular variant papillary thyroid carcinoma (FVPTC), and noninvasive follicular thyroid tumor with papillary-like nuclear features (NIFTP) (formerly noninvasive FVPTC) to identify useful cytological parameters for their differentiation. Nuclear grooves in the aspiration cytology of papillary carcinoma of the thyroid. Background: The cytological discrimination between benign and malignant follicular-patterned lesions of the thyroid can represent a diagnostic challenge, even for experienced pathologists. J Cytol. For full access to this pdf, sign in to an existing account, or purchase an annual subscription. An electron-microscopic study of human thyroid cancer. In the other six (75%) cases, a moderate to high proportion of neoplastic cells with nuclear grooves facilitated the diagnosis of papillary carcinoma. The follicular variant of PTC (FVPTC) is the most common variant after classic PTC, making up 10 to 15 % of all PTC [ 5, 6 ]. Clipboard, Search History, and several other advanced features are temporarily unavailable. 1979 Oct-Dec;17(4):233-9. Diff-Quik staining, ×10 magnification Papillary thyroid carcinoma distinction 477 In this study we analysed the cytological features of 14 histopathologically proven cases of FVPTC. Accessibility To attempt to clarify this diagnostic problem, we analyzed the BRAF status of thyroid tumors in a group of patients with follicular variant of papillary thyroid carcinoma (FVPTC) and its … The cells were arranged mainly in monolayer sheets and syncytial fragments; occasional microfollicle formation with abundant fine eosinophilic cytoplasm was seen. Dear Dr. Bedrossian, Being the most common neoplasm of the thyroid gland, papillary thyroid carcinoma (PTC) is the thyroid carcinoma that has been searched most and has had most number of variant. 350 W 11. th. FNA biopsy is very sensitive for the diagnosis of the conventional PTC. The hyalinizing trabecular adenoma can have the nuclear features of papillary carcinoma, and most case are diagnosed as suspicious or positive for papillary carcinoma by FNA. It is difficult to establish a diagnosis of the follicular variant of papillary thyroid carcinoma (PTC) using fine‐needle aspiration cytology (FNAC). All these features have been described for follicular lesions or neoplasia together with occasional nuclear grooves, as occurred in two (25%) of the studied cases. Cytologically, FVPTC contains cells that show the nuclear features of PTC, such as ground glass nuclei, nuclear grooves, The cytologic diagnosis of follicular variant of papillary thyroid carcinoma (FVPTC) can be difficult owing to the paucity of nuclear changes of papillary carcinoma and overlapping features with other follicular-de rived lesions. 1 - 8 In Diff‐Quik (Baxter Diagnostics, McGaw Park, IL)‐stained smears of 63 cases of FVPC, Gallagher et al. Nuclear cytoplasmic inclusions occurred in seven (87.5%) of the cases. 1 At the same time, however, disease mortality has remained constant. Identification of typical nuclear features in cytology helps in differentiating follicular variant papillary carcinoma from follicular neoplasms and, predominant presence of microfollicles favour follicular variant of papillary thyroid carcinoma (FVPTC). Cytojournal. The criteria for classification of well-differentiated thyroid carcinoma have changed from an emphasis on the histologic pattern of cellular architecture to a focus on the cytologic features characteristic of papillary and follicular carcinoma … Thyroid nodules with FNA cytology suspicious for follicular variant of papillary thyroid carcinoma: Follow‐up and management Sanjay Logani M.D. 2009 Jan 19;6:3. doi: 10.4103/1742-6413.45193. Molecular genotyping of papillary thyroid carcinoma follicular variant according to its histological subtypes (encapsulated vs infiltrative) reveals distinct BRAF and RAS mutation patterns. Synthesis and characterization of magnesium diboride nanosheets in alginate/polyvinyl alcohol scaffolds for bone tissue engineering. Rivera M, Ricarte-Filho J, Knauf J, et al. Encapsulated forms of the follicular variant with the absence of certain adverse features has led to another variant termed noninvasive follicular neoplasm with papillary-like nuclear features (NIFTP), which is currently considered to not be a cancer. Follicular variant papillary thyroid carcinoma (FVPTC) is the most common variant of papillary thyroid carcinoma (PTC) after classical PTC (CPTC). Cystic changes in primary tumor or in metastasis are not infrequent. Nuclear enlargement was a consistent finding in all cases. Follicles were identified in smears from seven cases (87.5%) and sheets reminiscent of a trabecular pattern in one (12.5%). Aging and the immune response in diabetic peripheral neuropathy. Bethesda, MD 20894, Copyright The cytological diagnosis of classical papillary carcinoma is easily established based on the characteristic architectural and nuclear features. Mod Pathol. 3 A dense globule of colloids of follicular variant papillary thyroid carcinoma. Fine-Needle Aspiration Cytology of Noninvasive Follicular Variant of Papillary Thyroid Carcinoma Is Cytomorphologically Distinct From the Invasive Counterpart. Cribriform-morular variant of papillary carcinoma: a distinctive variant representing the sporadic counterpart of familial adenomatous polyposis-associated thyroid carcinoma? Fine needle aspirates from 8 thyroid papillary carcinomas, follicular variant, were studied. Running Title: FNA Cytology of NIFTP . Fine-Needle Aspiration of Hürthle Cell Lesions: Accuracy of Thyroid Fine-Needle Aspiration Using Receiver Operator Characteristic Curves, Focal Features of Papillary Carcinoma of the Thyroid in Fine-Needle Aspiration Material Are Strongly Associated With Papillary Carcinoma at Resection. From the Department of Pathology and Laboratory Medicine, University of Pennsylvania Medical Center, Philadelphia. Although true follicular thyroid carcinoma is known to metastasize via the bloodstream and give rise to bone and lung metastases, such a pattern of spread is rare in papillary thyroid carcinoma. The goal of this study is to evaluate … An analysis of trends of incidence and cytohistological correlation of papillary carcinoma of the thyroid gland with evaluation of discordant cases. World J Surg. Fine-needle aspiration of the macrofollicular and microfollicular subtypes of the follicular variant of papillary carcinoma of the thyroid. Biopsy of the scalp swelling and thyroid nodule confirmed the same. Would you like email updates of new search results? This site needs JavaScript to work properly. US features, USFNA cytology, and FS results were compared based on the pathology results of patients with 2010; 23: 1191 – 1200 To evaluate the role of ultrasonography (US), US-guided fine-needle aspiration (USFNA) and intraoperative frozen section (FS) in follicular neoplasm. Jaffar R, Mohanty SK, Khan A, Fischer AH. 2016 Oct-Dec;33(4):192-198. doi: 10.4103/0970-9371.190455. 4 Ropy colloids, so-called chewing gum-like colloids, between tumor cells of conventional papillary thyroid carcinoma. 2010;23(9):1191-1200.Google Scholar Crossref Comparison of Nuclear Grade, Necrosis, and Histologic Subtype Between Biopsy and Resection in Pleural Malignant Mesothelioma: Implementation of a Sample Pooling Strategy for the Direct Detection of SARS-CoV-2 by Real-Time Polymerase Chain Reaction During the COVID-19 Pandemic: SATB2 Is Expressed in a Subset of Pulmonary and Thymic Neuroendocrine Tumors, Pathologic Spectrum and Molecular Landscape of Myeloid Disorders Harboring. Division of Cytopathology, Department of Pathology and Laboratory Medicine, Hospital of the University of Pennsylvania, Philadelphia, Pennsylvania Search for other works by this author on: © American Society for Clinical Pathology. Follicular variant of papillary thyroid carcinoma (FV-PTC) is defined by 2 features: Architecturally, it is composed exclusively or almost exclusively of follicles Cytologically, it shows nuclear features of papillary thyroid carcinoma, such as nuclear enlargement, nuclear membrane irregularity and chromatin clearing Background. Fine needle aspirates from 8 thyroid papillary carcinomas, follicular variant, were studied. Colloid material presented as intraluminal (one case) or extraluminal, dense, round masses (six cases). National Library of Medicine Micropatterned growth surface topography affects extracellular vesicle production. 2, 3 It was recently renamed as noninvasive follicular thyroid neoplasm with papillary-like nuclear features (NIFTP) because of its unique behavior and good … Unable to load your collection due to an error, Unable to load your delegates due to an error. the PTC family.1 The follicular variant of PTC (FVPTC) is the most common subset of papillary car-cinoma and is found in 9% to 22.5% of patients with PTC.2–5 This variant is composed entirely or almost completely of follicles, which are lined by cells that have the nuclear features of papillary carcinoma.6 The follicular variant of papillary carcinoma can be difficult to distinguish from a follicular lesion; the chromatin pattern can be helpful. However, the fact that—as above stated—on close examination one finds abnormal nuclei in the follicular cells within the nodule but outside the spots speaks against this interpretation and favors the alternative hypothesis that the entire nodule is a follicular variant of papillary carcinoma into which multiple foci of increased growth have developed. Background: Fine needle aspiration cytology (FNAC) is an important investigation in preoperative diagnosis of thyroid lesions. 8600 Rockville Pike Histologic examination showed encapsulated follicular-pattemed nodules with multifocal random distribution of nuclear features of papillary carcinoma that were more pronounced in the subcapsular locations of the lesions. Zubair W. Baloch, MD, PhD, Prabodh K. Gupta, MD, FIAC, Gordon H. Yu, MD, Martha J. Sack, MD, Virginia A. LiVolsi, MD, Follicular Variant of Papillary Carcinoma: Cytologic and Histologic Correlation, American Journal of Clinical Pathology, Volume 111, Issue 2, 1 February 1999, Pages 216–222, https://doi.org/10.1093/ajcp/111.2.216. We believe that these findings should be considered when interpreting follicular lesions; suspicion of an FVPTC should be conveyed in the cytopathology report, which may prompt intraoperative assessment to avoid a second surgical intervention for completion thyroidectomy. Author information: (1)Pathology Service, Dr. A. Onativia Endocrinology and Metabolism Hospital, Salta, Argentina. FVPTC has lower mortality and less frequent distant metastases than FTC, but higher mortality and more frequent distant metastases than cPTC. Am J Clin Pathol. Mesonero CE, Jugle JE, Wilbur DC, Nayar R. Endocrinologie. conventional papillary carcinoma (55-60%) and follicular variant papillary thyroid carcinoma (FVPTC, 23-41%).8 The neoplasm had a follicu-lar architectural pattern but the nuclear features were that of the conventional PTC.9 The recogni-tion of the FVPTC posed many problems at different levels. Preoperative features on ultrasound (US) imaging are different between follicular PTC and classic PTC. This morphologic heterogeneity explains the variability seen in FNA specimens of FVPTC and may result in false-negative diagnoses. 1 reported “tumor cellularity,” arrangement in empty follicles, … Privacy, Help Department of Pathology and Laboratory Medicine . The follicular variant of papillary thyroid carcinoma: characteristics of preoperative ultrasonography and cytology Follicular variant of papillary carcinoma is a common type of papillary thyroid cancer. 2016; 146(3):373-7 (ISSN: 1943-7722) Ibrahim AA; Wu HH Ultrasound-guided fine-needle aspiration biopsy (FNAB) is the recommended modality for the evaluation of suspicious thyroid nodules. Correlation of cytologic and histologic features in variants of papillary carcinoma of the thyroid. Hemosiderin laden macrophages and hemosiderin within follicular cells distinguish benign follicular lesions from follicular neoplasms. Diagnosis of follicular variant (FV) of papillary carcinoma (PC) of the thyroid is considered difficult on cytology. Introduction. Follicular variant PTC was considered to be present in cases of PTC showing a follicular growth pattern with virtually no papillary structures along with nuclear features of papillary carcinoma. noninvasive encapsulated follicular variant of papillary thyroid cancer (EFVPTC) FOIA 2004 Sep;28(9):880-5. doi: 10.1007/s00268-004-6953-z. Prevention and treatment information (HHS). Careers. Follicular variant of papillary carcinoma thyroid (FVPTC) is a well defined entity in histopathology, but its diagnosis in FNAC is usually missed and is challenging compared to classic papillary thyroid carcinoma. Please enable it to take advantage of the complete set of features! There are several studies on the cytologic clues improving the diagnostic accuracy. Cytologic findings in the follicular variant of papillary carcinoma of the thyroid. 2 The However, the follicular variant of papillary thyroid carcinoma(FVPTC) poses a diagnostic challenge. The follicular variant of papillary thyroid carcinoma (FVPC) is now recognized as a distinct subtype of papillary thyroid carcinoma (PC) (1., 2., 3., 4., 5. In cases of FV PTC where the nuclear features diagnostic of cancer were only focal or multifocal within the nodule, the total nodule size was used for staging purposes. Fine-Needle Aspiration Cytology of Noninvasive Follicular Variant of Papillary Thyroid Carcinoma is Cytomorphologically Distinct from the Invasive Counterpart . Fig. Authors: Ashley A Ibrahim, MD . Molecular genotyping of papillary thyroid carcinoma follicular variant according to its histological subtypes (encapsulated vs infiltrative) reveals distinct BRAF and RAS mutation patterns. Copyright © 2021 American Society for Clinical Pathology. Our findings suggest that a careful microscopic search for nuclear grooves should be attempted in aspirates yielding a diagnosis of follicular neoplasia that could otherwise be indistinguishable from the follicular variant of papillary carcinoma of the thyroid. Most of papillary thyroid carcinoma are infiltrative while some are encapsulated or well demarkated (usually follicular variant) Tumor stroma could be fibrotic (predominant in fibromatosis / fasciitis-like variant) or calcified and ossified. Ultrasonography (2016-01-01) . On the contrary, reported sensitivity of FNA in FVPTC is significantly low [ … The noninvasive encapsulated follicular variant of papillary thyroid carcinoma (EFVPTC) is an example, accounting for 10% to 20% of all thyroid cancers currently diagnosed in Europe and North America. Methods. Diff-Quik staining, ×20 magnification Fig. Since the introduction of FNAB, the incidence of thyroid carcinoma has nearly tripled. Papillary thyroid carcinoma (PTC) is the most common malignancy of the thyroid gland [1,2], and numerous variants of PTC have been reported with distinct histopathological features [].Conventional or classical PTC is the most frequent type, while the follicular variant of papillary thyroid carcinoma (FVPTC) is the second most common variant; … All cases showed increased cellularity and a background of moderate to abundant thin watery colloid with variable amounts of thick eosinophilic colloid. Harach HR(1), Zusman SB. We report our fine-needle aspiration (FNA) experience with 17 histologically proved cases of FVPTC with a preceding FN A. The prognosis of thefollicular variant of papillary thyroid carcinoma (FVPTC) falls between that of classical papillary thyroid carcinoma (cPTC) and follicular thyroid carcinoma (FTC) (1). Role of fine-needle aspiration biopsy and frozen section in the management of papillary thyroid carcinoma subtypes.
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